Independent component analysis for assessing therapeutic response in vitiligo skin disorder

M.H.A., Fadzil and S., Norashikin and H.H., Suraiya and H., Nugroho (2009) Independent component analysis for assessing therapeutic response in vitiligo skin disorder. [Citation Index Journal]

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This paper describes an image analysis technique that objectively measures skin repigmentation for the assessment of therapeutic response in vitiligo treatments. Skin pigment disorders due to the abnormality of melanin production, such as vitiligo, cause irregular pale patches of skin. The therapeutic response to treatment is repigmentation of the skin. However the repigmentation process is very slow and is only observable after a few months of treatment. Currently, there is no objective method to assess the therapeutic response of skin pigment disorder treatment, particularly for vitiligo treatment. In this work, we apply principal component analysis followed by independent component analysis to represent digital skin images in terms of melanin and haemoglobin composition respectively. Vitiligo skin areas are identified as skin areas that lack melanin (non-melanin areas). Results obtained using the technique have been verified by dermatologists. Based on 20 patients, the proposed technique effectively monitored the progression of repigmentation over a shorter time period of six weeks and can thus be used to evaluate treatment efficacy objectively and more effectively. © 2009 Informa Healthcare USA, Inc.

Item Type: Citation Index Journal
Uncontrolled Keywords: Haemoglobin; Image analysis techniques; Objective methods; Skin disorders; Therapeutic response; Time periods; Vitiligo; Image analysis; Independent component analysis; Skin; Principal component analysis; Algorithms; Computer Simulation; Humans; Image Processing, Computer-Assisted; Photography; Principal Component Analysis; Skin; Skin Pigmentation; Vitiligo
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Departments / MOR / COE: Departments > Electrical & Electronic Engineering
Depositing User: Prof Ir Dr Ahmad Fadzil Mohd Hani
Date Deposited: 09 Mar 2010 01:08
Last Modified: 19 Jan 2017 08:25

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