A quadruplet 3-D laser scribed graphene/MoS2 functionalised N2-doped graphene quantum dots and lignin-based Ag-nanoparticles for biosensing

Vasudevan, M. and Perumal, V. and Raja, P.B. and Ibrahim, M.N.M. and Lee, H.-L. and Gopinath, S.C.B. and Ovinis, M. and Karuppanan, S. and Ang, P.C. and Arumugam, N. and Kumar, R.S. (2023) A quadruplet 3-D laser scribed graphene/MoS2 functionalised N2-doped graphene quantum dots and lignin-based Ag-nanoparticles for biosensing. International Journal of Biological Macromolecules, 253. ISSN 01418130

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....


Troponin I is a protein released into the human blood circulation and a commonly used biomarker due to its sensitivity and specificity in diagnosing myocardial injury. When heart injury occurs, elevated troponin Troponin I levels are released into the bloodstream. The biomarker is a strong and reliable indicator of myocardial injury in a person, with immediate treatment required. For electrochemical sensing of Troponin I, a quadruplet 3D laser-scribed graphene/molybdenum disulphide functionalised N2-doped graphene quantum dots hybrid with lignin-based Ag-nanoparticles (3D LSG/MoS2/N-GQDs/L-Ag NPs) was fabricated using a hydrothermal process as an enhanced quadruplet substrate. Hybrid MoS2 nanoflower (H3 NF) and nanosphere (H3 NS) were formed independently by varying MoS2 precursors and were grown on 3D LSG uniformly without severe stacking and restacking issues, and characterized by morphological, physical, and structural analyses with the N-GQDs and Ag NPs evenly distributed on 3D LSG/MoS2 surface by covalent bonding. The selective capture of and specific interaction with Troponin I by the biotinylated aptamer probe on the bio-electrode, resulted in an increment in the charge transfer resistance. The limit of detection, based on impedance spectroscopy, is 100 aM for both H3 NF and H3 NS hybrids, with the H3 NF hybrid biosensor having better analytical performance in terms of linearity, selectivity, repeatability, and stability. © 2023 Elsevier B.V.

Item Type: Article
Impact Factor: cited By 0
Uncontrolled Keywords: Biomarkers; Biopolymers; Blood; Charge transfer; Layered semiconductors; Lignin; Metal nanoparticles; Molybdenum compounds; Nanocrystals; Nitrogen; Semiconductor quantum dots; Silver nanoparticles; Sulfur compounds, Biosensing; Blood circulation; Electrochemical sensing; Functionalized; Human bloods; Hydrothermal process; Myocardial injury; Nitrogen-graphene; Sensitivity and specificity; Troponin, Graphene, Blood; Charge Transfer; Molybdenum Compounds; Nitrogen; Sulfur Compounds
Depositing User: Mr Ahmad Suhairi Mohamed Lazim
Date Deposited: 04 Oct 2023 08:29
Last Modified: 04 Oct 2023 08:29
URI: http://scholars.utp.edu.my/id/eprint/37261

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